Diet is known to alter the gut microbiota. Is it likely that processed foods and high glycemic index foods may bring about such a change which in turn may lead to inflammatory and other changes progressing to diabetes?
Dear its well known that H. Pylori as antral mucosal spiral rod bacteria cause secondary Diabetes as well as other endocrinopathies as thyroiditis
The paths to type 2 diabetes are complex and inter-related. Poor diet contributes to the inflammatory process. Concurrently, change in gut micro-flora may also lead to inflammation and cause endocrine diseases.
Thanks Dr. Bashir but do all people harboring H. pylori develop diabetes? and what of the duodenal and intestinal mirobes?
Thanks Dr Arvindekar as its well known thar H. Pylori are highly antigenic and 6 fold carcinogenic (WHO) as it is attack by specific IgG & IgA attached to EGF receptors at genetically affected cell to transducted and expressed. So it is known that affects endocrinal cells, thyoid, pancreas to cause thyroiditis and Diabetes Mellitus and of course not the only cause for secondary DM so not all people harboring H. Pylori although it affects almost 50% of world population. H. Pylori inhabit antral mucosa and affect stomach, duodenumand oesphagus to cause gastritis, doeudenitisand oesphagitis.
Recently published studies suggest that the microbiota is one of the central factors in diabetes development. However, there have been no published results to date of studies that have followed up prediabetics evaluating the microbiota and can demonstrate temporality and a causal effect in diabetes. Here I send you attached a copy of the work of my team in the area, I hope you find it useful :)
Article Fecal microbiota imbalance in Mexican children with type 1 diabetes
A recent study have been done at Extradigedtive H. Pylori Skin manifestations EdHpSm published at CRO vol. 3 (2) pp 24-19 Feb 2012 Bashir AHH, Yousif SM and Mahmoud MOA.
The study "A metagenome-wide association study of gut microbiota in type 2 diabetes" published in Nature 490, 55–60 (04 October 2012) showed that "patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. "
@ Akalpita Arvindekar
The answer to your question is "Yes". Kindly see the following references.
Article Gut microbiota and diabetes mellitus- an interlinkage
Article Gut Microbiota and Type 1 Diabetes
Article The role of gut microbiota in the development of type 1, typ...
Article Understanding the role of the gut ecosystem in Diabetes Mellitus
Article The Role of Gut Microbiota in Obesity and Type 2 and Type 1 ...
Article Impact of the gut microbiota on the development of obesity a...
Thanks!
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