Necrosis leading to regression of HCC tumor is a rare event. However, spontaneous hemorrhage in 5-15% of HCC have been reported. This adds to complication in patient management. Both surgical intervention and anti-angiogenic therapy are prescribed.

It depends as to whether the patient has undergone any type of an intervention such as chemoembolisation in order to deal with the tumour Article Embolization of liver tumors: Past, present and future

If the patient has undergone some type of intervention to deal with the HCC then the presence of necrosis may reflect a response to the treatment that was delivered either locally and/or regionally to the HCC. If the patient has not undergone any specific treatment for the HCC then the presence of necrosis could signify that the HCC was rapidly growing (i.e. it was more malignant) and hence it outgrew it's blood supply.

Necrosis and hemorrhage in any untreated malignant tumour are usually signs of higher tumour grade, i.e. more rapid growth and increased malignant behaviour.

Induced or simultaneous intratumoral necrosis, hemorrhage or hemorrhagic necrosis can be utilized in a targeted pan-anticancer theragnostic strategy (see Li et al, Radiology 2011; 260:799-807).

This correlate with a worse stage HCC ; kindly see the Barcelona staging of HCC as well as AASLD guide for HCC treatment and response

If interested, you may google "oncocidia" to view a short video about the above-mentioned necrosis-targeted pan-anticancer theragnostic strategy.

In some cases is a good sign going to spontaneous reduction of size of the tumor and in a few cases leading to the temporary disappearance

induced necrosis by local ablative therapy is agood sign while hemorrage is a bad sign as it indicate possibility of rupture hcc which is a poor prognostic sign