It is safe for use in wounds located where there is no danger of the material being swallowed.

Try looking up this reference:  Cochrane Database Syst Rev. 2004;(2):CD004287.

Tissue adhesives for closure of surgical incisions.

Coulthard P1, Worthington H, Esposito M, Elst M, Waes OJ.

Yes is safe and is a component of others adhesive cyanocrylates!!

Definitely NOT SAFE for intra-oral use. Look at this report in new York times: http://www.nytimes.com/health/guides/poison/cyanoacrylates/overview.html

Yes its safe, so long as it doesnt enter the under the flap, else it might lead to foreign body reaction and pus formation/abscess. Suitable to passive flap closure (where you dont need to coronally or apically displace the flap, or vertiacal incisions. You can also used it as an adjunct, whereby youll need less number of sutures. So few sutures at wide gap will hold the flap in position and adhesive will support complete flap closure.

I've also used it so seal gingival sulcus in patients where full mouth local drug delivery was done. It was very convinient and comfortable to use with no side effects.

Dear : Dr.Jyothilekshmi Velayudhan

Your question : Is N- Butyl Cyanoacrylate adhesive safe and suitable for intraoral wound closure? I would like to do research on this topic.

My answer is backed by scientific data as well as personal experience in research on Cyanoacrylate.

I had a huge grant form the government of Canada to do research on N- Butyl- Cyanoacrylate so I would consider my self knowledgeable in this area plus I published several appears in this area after applying N-Butle-Cyanoacrylate on the skin and in the oral mucosa

Here is the  answer to you question is it safe or not it is safe if use d with reasonable cautiousness.  My research shows that wound healing would occur if used correctly and I mean by that do not let the N-Butyl Cyanoacrylate go below the surface of the wound (in the subcutaneous area)  It has to be on the surface otherwise my research shows that any tissue adhesive  below the skin or oral mucosa  will be a foreign body reaction so keep the adhesive on the surface  and it  will function better.

One of the colleagues who answered this question is -with all due respect- wrong in that he posted  a report in new York times saying that it is  poison and here is the report “he is the third answer in this questionnaire and here what he says

Solomon O Nwhator · 25.06 · Obafemi Awolowo University Definitely NOT SAFE for intra-oral use. Look at this report in new York times: http://www.nytimes.com/health/guides/poison/cyanoacrylates/overview.html  “

My answer to the new York article is  that they  are talking about  Methyle-Cyanoacrylate which in USA and Canada is some times sold under the name  called Crazy glue and may be in other parts of the world .Crazy glue is Methyle-cyano acrylate . one should remember that  the company which makes Crazy glue never recommend using it on humans it is used for gluing steel wood and plastics but not for humans

All the research done on Methyle-cyano-acrylate in the 1960’s and 1970’s shows that  it is absolutely carcinogenic. In the Vietnam war Methyle-cyano Acrylate  was used to stop bleeding and adhere tissue especially in a lacerated liver  ,almost all military people who were administered MethyleCyano Acrylate  had cancer of the liver because Methyle-cyano Acrylate  was used directly on  livers severed by bullets in the Vietnam  war. You can read all this in this fantastic Research book written by a United States Army Doctor by the name of Dr .Teruo Matsumoto..and here is the title of the Book: which was published in 1972

Tissue adhesives in surgery  By ,Dr. Teruo Matsumoto ,Medical Examination Pub. Co., 1972 - Medical - 508 pages

I have enclosed here  my publication and an image of N-Butl Cyanoacrylate applied  to the back of mice in one of my studies

Best wishes

Dr.K.A.Galil.Professor of Dentistry

DDS.,D.Oral & Maxillofacial Surgery,PH.D,FAGD.,FADI.,Cert.Periodontist (Royal College of dental surgeons )

,Developer of The patented first App in Oral Histology for i Pad,i Phone ,i Pod Touch

visit the web site

https://itunes.apple.com/us/app/dgohe+/id1015383607?mt=8

and down load a free demo ,look at the bottom of the page

see Dr.Galil listed as #17 on the  51 first researchers in the history of Western university and the only dentist to be included

http://www.uwo.ca/research/51_firsts/

https://www.uwo.ca/research/about/publications.html

here is the list of my publications