Is it valid to compare the wild type protein against the protein that has been truncated due to stop codon mutation using molecular dynamics simulations?
Dr Thirumal Kumar D Sir, did you find any solution to this? Pls share. DM.
Anwesh Pandey No idea brother. I am still wondering if someone can help us with valid justifications. But I personally feel that it could be possible as truncated in sense, the entire translation process is stopped there might not be a rise of protein at all. But I am not pretty sure about this still.
As far as i think, if the truncation is towards the end terminals and if those terminals do not lie in the active site then possibly we can do te md. But i need more justification to this. Lets see if someone on RG answere this.
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