Suppose one has a 1-D, homogeneous heat equation
rm*Cp*T_t = -lm*T_xx
(with rm being the density of the material, Cp is the heat capacity coefficient; lm is the thermal conductivity of the material being studied) , with Robin boundary conditions that depend both on time and space. For example, suppose that the boundary condition includes a heat source, convection and radiation:
q0 + hconv(Tenv-T(x,t)) + sigma*em*(Tenv^4-T(x,t)^4)
where q0 is a heat source, hconv is the convection constant, Tenv is it environment temperature, sigma is the Stefan-Boltzmann constant, em is the emissivity and T(x,t) is the function of temperature to be solved for, meaning that it is the same function to be solved for in the heat equation.
I would say that it is not the case that this partial differential equation can be solved using separation of variables. Or can't it? The point being, I do not have a mathematical or physical argument to actually be convinced that such is the case, or not.