Could the structure/spatial folding of the hippocampus lead to closed field activity that cannot be recorded on the scalp surface? Or might the location of the structure in general be too deep to get a reliable signal?
I know only of a very few studies (EEG/MEG) that claim to have recorded hippocampal activity and most of these have used beamforming or other reconstruction approaches with strong model assumptions.
I am happy to learn from researchers using EEG/MEG to analyze hippocampal activity in humans.
Here is a study that suggests
a certain wave object called
ν-complexes (Nu-complexes)
can be used to deduce hippocampal
activity.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0075257
Regards,
Joachim
You can record potentials from the brainstem by averaging (AER,BAEP...) so there is to me no reason why you can't record from hippocampus. However, due to a set of reasons including the issues you point to it seems practically very difficult. I have myself tried setting up models a few times, but I have not found solutions I can believe in. The most important part is to get rid of the "noise" made by the neural activity over the convexity between the electrode and hippocampus.
A recent study provides direct evidence that human hippocampal low-frequency oscillations can be detected with EEG/MEG using simultaneous MEG/depth electrode recordings.
Check out Figure 2 in :
http://www.hal.inserm.fr/file/index/docid/823750/filename/DalalEBM.pdf
Best,
-Andrew
Have a look to R. Roman work who record ERPs with electrodes implanted into the hippocampi of epileptic patients.
http://onlinelibrary.wiley.com/doi/10.1002/hipo.22173/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false
All the best,
Laurence
Pierre Mégevand et al. found that interictal discharges in high density EEG could be accurately localized to the medial temporal lobe (where subsequent intracranial EEG recordings were used to identify the presumed true source of the interictal discharges):
http://jnnp.bmj.com/content/85/1/38.short
Electric source imaging of interictal activity accurately localises the seizure onset zone
J Neurol Neurosurg Psychiatry 2014;85:38-43 doi:10.1136/jnnp-2013-305515
recently published: Non-invasive Investigation of Human Hippocampal Rhythms Using Magnetoencephalography: A Review
Yi Pu • Douglas O. Cheyne • Brian R. Cornwell • Blake W. Johnson
we have just published an article on the topic (in open access)
Deep brain activities can be detected with magnetoencephalography.
Pizzo F, Roehri N, Medina Villalon S, Trébuchon A, Chen S, Lagarde S, Carron R, Gavaret M, Giusiano B, McGonigal A, Bartolomei F, Badier JM, Bénar CG.
Nat Commun. 2019 Feb 27;10(1):971
best regards
Christian
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