Do you mean "zero electrical resistance" ?
In this case you're talking about "superconductor" and the answer is No.
Some improvement in the physical properties is possible for thin films of copper deposited under specific conditions. 100% is extremely ambitious.
It is impossible without any addition to cooper. E.G. to make composite material with silver. Another way perhaps could be in case of nanowire. I met a paper where wire conductivity sharply change with diameter decrease.
Incorporating carbon into copper via electrolytic co-deposition of single wall carbon nanotubes and copper can improve conductivity by 30 percent or more.
I assume you mean 100% IACS conductivity (58 MS/m) in which case of course the answer is yes.
Copper Wire Tables Circular No. 31. US Bureau of Standards, 1913.
https://archive.org/download/copperwiretables31unituoft/copperwiretables31unituoft.pdf
From some suppliers you should even be able to achieve more than 100%. Copper production has improved in the last 100 years.
http://en.wikipedia.org/wiki/Oxygen-free_copper
To change conductivity of some material you need to chanche whether temperature-pressure or the material composition. Without these changes it is impossible to increase (or decrease) the conductivity of any substance or material. So if it is important for you to keep the temperature and pressure then the only way is to change the composition.
Over internet I found the conductivity of copper can be increased slightly by adding oxygen (small fraction~ 0.02-0.05%). Conductivity changes from 5.8e7 S/m to 5.865e7 S/m (101 %).
https://www.911metallurgist.com/copper-electrical-conductivity/
your mean super conductor at room temperature
https://en.wikipedia.org/wiki/Room-temperature_superconductor
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