I am intrigued by the association of periodontitis with various systemic disease. a constant explanation is the role of P.Gingivalis and other pathogens acting as source of immune hyperesponsiveness. several studies have proved this. I personally feel, if the association is true we should be able to develop a single model to prove this .
Dear Rodrigo Guabiraba,
Thanks for your answer. I completely agree with you. But what perplexes me is that every day new reports of association of new systemic disease from Alziemers to diabetes mellitus with periodontitis is being published. But, we see these systemic disease in edentulous patients also where periodontitis does not exist. This provoked a thought in my mind that if we are able to develop an animal model where we can establish a direct link between systemic disease and periodontitis, this should add more authenticity to the already existing results. What is your opinion?
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