If I am preparing a herbal formulation with extract and I want the dissolution studies of the same, is it possible to estimate percentage cumulative release (because for estimation of this we need claimed amount of drug and the extract contain number of phtoconstituents) ?
Well, that might be a tricky issue. I´d say it depends how many different substance are in your extract, what are their absorption spectra, are they release at the same time and rate and what did you formulate them with. Also, the important questions is what equipment you have available. If you have an HPLC with an diode array detector, this might be relatively straightforward.
Dear Devesh, a number of related papers are available on line which you can get through net-browsing. See two of them as attachment :))
Best Wishes
Dear Dr Tiwari ,First you done HPLC /LCMS of formulation with standard of known marker,after that you done dissolution study you easily find conc of each compund marker.
Respected all.... I am highly thankful for your valuable reply, I will be highly benefited from your suggestions.....
- Badges
- Science topic
- Similar topics
- Methodology
- Research Methodology
- Research Papers