Deoxycorticosterone acetate (DOCA) is commonly used to induced hypertension in experimental animals after the left kidney has been removed. is it possible to induced hypertension with DOCA without the left kidney being excised.
Yes, I thought for a long time that uninephrectomy was necessary, but it is not.
We have just been giving a Doca pellet and 1% salt to drink. Blood pressure increases similarly to the one kidney model. One does not see the massive renal hypertrophy which accelerates and complicates evaluation of the effects of hypertension on the progression of kidney disease.