Any good In Vivo and In Vitro Models for testing pyrazinoic acid for chronic TB infection?

Olumide FRANKLIN Afinjuomo @Olumide-Afinjuomo

16 December 2017 1 4K Report

Please can someone suggest any In Vivo and In Vitro Models for testing pyrazinoic acid( the active metabolite of pyrazinamide) to establish the non-replicating efficacy in Chronic TB infection

Qin Xiang Ng

Hi,

I believe mice are commonly used to study chronic Mycobacterium tuberculosis infection

(see: Article In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuber...

As for in vitro studies, murine cells or human macrophages infected with M. tuberculosis have been used (see: Article NOD2 controls the nature of the inflammatory response and su...

Hope this helps!

Best regards,

Qin Xiang

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