Can anybody explain association of Hypertension with High density lipoprotein, I am doing an analysis and the protective association is coming out between low levels of HDL with presence of hypertension.
What could be the possible explanation, is there any biological plausibility or any other explanation of this phenomenon.
Note: The sample size is adequate, the study is powered statistically and there is no misclassification. Multivariate analysis has also done appropriately with adjusting for potential confounders.
Hi,
I would not say a protective effect. The article "High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease". Hypertension. 2000; 36: 226-232 may bring some insight into your questioning. Peace and blessings.
http://hyper.ahajournals.org/content/36/2/226.full
I think you should consider the concentrations of LDLc. Often hypertriglyceridemia is accompanied with low HDL by simple transfer of cholesteryl esters from HDL to VLDL and I have nothing clear that an isolated hypertriglyceridemia is atherogenic. Another question is if it is part of a metabolic syndrome or combined hyperlipidemia with increased LDL.
Adeel are you finding low HDL is associated with low to normal blood pressure? Since high HDL is considered protective of cardiovascular health, this finding is unusual, when considering control variables. Is it possible that persons put on hypertension medications also had low HDL? I do not think there is a biological explanation for low HDL preventing hypertension.
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Medical Pharmacology
- Clinical Pharmacology