Is it possible that an increase in central nerve system activity would lead to an increase in beta3 AR levels?

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I was wondering if an increase in neurotransmitters such as NE will lead to an increase of B3AR expression?

Based on general rule which states: higher level of ligand leads to downregulation of receptors, we roughly conclude that the B3AR gene may underexpress. Please review the Kd and other kinetics parameters in this context.

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