Dear Phuoc-Tan!

Please You look at the articles:

Article RAGE regulates oxytocin transport into the brain

We reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-products (RAGE) in endothelial cells at the blood−brain barrier. Additionally, we found that oral oxytocin is absorbed by RAGE on intestinal epithelial cells at the blood−intestinal barrier.

Article Oxytocin depolarizes mitochondria in isolated myometrial cells

Oxytocin is known to play important roles in uterine contractions, mediated at least in part by increasing intracellular Ca(2+) concentration ([Ca(2+)](i)), through enhancing extracellular Ca(2+) entry and Ca(2+) release from the sarcoplasmic reticulum, processes that are intimately linked with mitochondria. This study examined the effects of oxytocin on mitochondrial function.

Article Mitochondria, Oxytocin, and Vasopressin: Unfolding the Infla...

Oxytocin, vasopressin, and mitochondria - is there a direct link?

Of course, if oxytocin is transported intracellularly through RAGE, RAGE is present inside the caveolae, and caveolae interact with mitochondria, then oxytocytin can affect mitochondria.

Dear Alexandr,

Thank you very much. That is helpful.

It is good to know that you think it is plausible.

Phuoc-Tan

Thank you for nice question. Of course, if oxytocin is transported intracellularly through RAGE, and RAGE is present inside the caveolae, and caveolae interact with mitochondria, then oxytocytin can affect mitochondria.

Thank you Md. Nazmul Hoque.

It is helpful to know that the logic is reasonable.

I have found an article that shows oxytocin receptors are present on the nucleus...

Can GPCRs such as oxytocin move from the nuclear membrane to the mitochondria?

Thanks

Phuoc-Tan