It is confusing concept in the literature that some papers use the term "HER2 positive" and some "HER2 overexpression". You may refer to the definition in the specific paper, but sometimes they even dont mention what they mean with "HER2 positive" cell.
Any clarification would highly appreciated.
No. While generally cell lines with higher ERBB2 gene copy number have over-expressed HER2, some with normal copy numbers have over-expressed HER2 as well. Currently, there is really no universally accepted threshold for declaring HER2 over-expression in cell lines. But there are cell lines that have obviously over-expressed HER2 like BT474 and SKBr3.
It depends on the cell line. "Overexpression" can be defined as a state in which the expression is higher (e. g. after a treatment) than in the"normal" state - this needs to be compared.
Hope this helps
WD
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