We started using NaOH dissolution for liophylized recombinant amyloid beta 1-40 in order to dissolve preformed aggregates, but somehow we found that there is some degrdation in our sample, we are currently using EDTA and protease inhibitors after the dissolution.
It is recommended solvent, please see other solvents. Use HPLC to remove doubts
https://www.merckmillipore.com/INTL/en/product/-Amyloid-1-40-a-F4W-TFA-recombinant-human,MM_NF-AG918?ReferrerURL=https%3A%2F%2Fsearch.yahoo.com%2F&bd=1
The degradation is most probably due to alkali hydrolysis. Try volatile alkali such as ammonia instead.
There is the possibility that you are using too high concentration of NaOH. You can check the attached Abcam protocol to dissolve the ab peptide, where they suggest to use 10mM NaOH, and other methods,
Good Luck
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