My student has a solution of 0.8 g/ml of cocaine in distillate water stored at 5oC (diluted last week). However he will be running his experiments within a year. Should he worry about hydrolysis? I am attaching an interesting paper in this regard. Please I would like to read some comments about it, since I am inclined to ask him to evaporate this solution and return cocaine to solid phase.
We know of many organic compounds, for instance certain vitamins, that stability in an aqueous environment is not good at all, so yes I would worry and not start those experiments till I know the self life of such a solution.... Your paper already shows a 10% decrease in 1 month and suggest further stability...and the pH dependency of its stability is another issue...,but mind you the paper was 30+ years old...
We find such solutions stored under similar conditions to be quite stable. Just to be safe, however, we make fresh solutions each week.
In my experience as a forensic toxicologist, we stored our cocaine standards in acetonitrile at -30 degrees C. Many drugs can be stored in methanol, but ACN is better at preventing hydrolysis. Cerilliant ships their standards in ACN.
Hello,
Perhaps have a look at this paper http://www.forensicscience.pl/pfs/44_kiszka.pdf I found it useful when considering storing cocaine in solution. However, this was done in PBS rather than H20.
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