I am investigating effects of chlorogenic acid in the CNS and I want to understand the mechanism of these effects. Please help me by telling me some data clearly indicating if chlorogenic acid is present in brain tissue or not at all.
The review shown below may help to shed some light on the topic. Chlorogenic acid and its derivatives are dietary polyphenols with important bioactivities.
Caffeine and chlorogenic acids in coffee and effects on selected neurodegenerative diseases. Maia, Santos Roseane Maria; Tracy, Hunter; Nick, Wright; Andrade, Lima Darcy Roberto
A review. Much controversy and misunderstanding has surrounded the disputed health impact of coffee consumption. Recent studies now help clarify the pharmacol. and neurol. health promoting properties of coffee daily intake. Benefits are shown attributable to coffee's rich phytochem. that includes (besides caffeine) , phenolic compds., such as chlorogenic acids, diterpenes, trigonelline, minerals, amino acids and other volatile compds. It is also a powerful disease fighting antioxidant, the primary source of antioxidants in several countries. The purpose of this article is to review results from current epidemiol. and mechanistic studies on the central nervous system attributed to coffee. A primary focus to this review is the activity of caffeine and chlorogenic acids and their implications to CNS health. The discussion will highlight possible mol. mechanisms responsible for the resp. pharmacol. benefits.
Journal of Pharmaceutical and Scientific Innovation, Volume 2, Issue 4, 9-17, 9 pp., 2013, DOI:10.7897/2277-4572.02443
Below are several links showing the (known) effects of chlorogenic acid in the CNS and its availability in the body, as determined by plasma and urine mass spectrometry.
Link 1: Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia.
Link 2: Cognitive and neuroprotective effects of chlorogenic acid.
Link 3: Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons.
File 1: Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans
Hope these help. If you need any more sources for your research, don't hesitate to ask.
http://www.ncbi.nlm.nih.gov/pubmed/22659584
http://www.ncbi.nlm.nih.gov/pubmed/25130715
https://www.ncbi.nlm.nih.gov/pubmed/22580132
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