Hormon replacement, as well as oral contraceptives remain as two-edged  sword, since sexual hormones are capable of inducing protective or deleterious effects on liver diseases, depending on several factors, the very disease, age, estrogens or progestins type administered to women, genetic propensity, etc. Given the complexity of primary billiary cirrhosis, as it has been recognized as an autoimmune injury; I invite you to read my last article wherein you may find any further information which perhaps helps you. You will please find it attached.