As a researcher in the field of gastric cancer, I was interested in anti-cancer effect of pantoprazole. Most of works published about anti-cancer effects of pantoprazole in gastric context include SGC-7901 cell line. It is while we are using AGS cell line as a gastric model. I wonder if there are any special reasons behind choosing SGC-7901 instead of AGS. and if AGS could be used to study anti-cancer effects of pantoprazole.
From what I can see many of the paper studying the anti-cancer effects of pantoprazole in gastric carcinoma cell lines are from China. The SGC-7901 cell line:
https://web.expasy.org/cellosaurus/CVCL_0520
has been established in China and is used there much more than AGS. So that may be the simple explanation why it is used in that specific context.
Best
Amos
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