No. At the most fundamental level, Interpretation of physical theory by mathematics may not be appropriate. The reason-
"Suppose a Circle of radius zero and with theta(zero) radians. It is physically a point. But a point also will have radius(how ever small it may be, it will have a radius).So point is two dimensional or we can say one dimensional but we can not say zero dimensional. Thus a 'zero dimensional' object can not be interpreted by mathematics".
In physics-
" Suppose a quantum particle like photon.Space is zero for it . So every thing is zero for it.Even energy also should not exist, since there is no length(one dimension)or space (three dimensions). It is a quantum particle of EM force.
By quantum physics ,it can be explained as zero dimensional object.That means ,it is not even a point in space(nothing-since space zero as per physical meaning) but it will have some thing which can be explained by quantum mechanics .Thus zero dimension can be explained by physics.
Then Why physics is completely dependent on mathematics? Why mathematics is dominating in theoretical physics? Is it reasonable?. It is an important point in synchronization of QM with GR.