Hello, I am trying this channel to find somebody who would like to to cooperate on abdominal aortic aneurysm (AAA) research. As you may know my goal is to predict AAA rupture. We have developed probabilistic rupture risk index (Polzer and Gasser 2015) which calculates the probability AAA will rupture. So far the results are very promising (polzer et al. 2020) but I need more cases. The inclusion criteria are:
1) patient have CT on which AAA is intact
2) you know that AAA ruptured within one year from the CT
As you can imagine such cases are extremely rare. We searched databases of two large centers covering population of 3milions ten years back and found 11 cases. I would like to triple those numbers to perform solid validation of our index. I am not interested in cases which are already ruptured on CT since rupture changes the AAA geometry significantly and such validation cannot be therefore called blinded.
So if you have any case that meet the inclusion criteria and you are interested in improving AAA management, please let me know.
Stan Polzer
Hello!That's great. So do you have any cases which meets the inclusion criteria? If so I would need anonymized CT and basic patient information (sex, age, blood pressure, etc.) sex and blood pressure is vital, the rest depends on your database.
Dear Mr Polzer,
I am an interventional radiologist working in a cardiovascular clinic and I am doing EVAR.
If I may help you I do it gladly.
Is it a prospective or retrospective study ?
Sincerely,
Geoffrey Colin, M.D, Clinique St-Luc Bouge, Namur, Belgium
Geoffrey C Colin Dear Dr Colin,
thank you for your interest. I do not favor any type of intervention (as I do not have knowledge for it) I just want to validate that my tool can predict incoming rupture better than maximal diameter. I.e. same sensitivity with lower false positive rate (very important during current pandemic). It is retrospective study. The important thing is we need to know the outcome (rupture) in one year but it cannot be obvious from the CT. If you have patients like that I would need their anonymized CT-A with basic information (blood pressure, sex,etc.). Whatever you can find it would be best if could mix it with patients for which you know their AAA did not rupture in one year so it would be blinded for me. It is not necessary to have the diameter matched groups, just please keep the ratio ruptured/intact 1:3 or less.
I do not have any specific demands on the quality of the CT-A. Of course the finer resolution is always better but I am not picky considering how rare those cases I am looking for are.
Best Regards,
Stan
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