Just out of curiosity - lets consider an obese individual with impaired glucose uptake, moderate fasting elevated blood glucose, insulin resistance and consistent hyperinsulinemia. Suppose he/she undergoes a treatment that qualitatively and quantitatively improves insulin sensitivity, what is it going to be wrt cellular glucose metabolism and lipid profile? Will it be dangerous if the treatment improves insulin sensitivity wrt to glucose homeostasis but somehow fails to bring down hyperinsulinemia?
Generally hyperinsulinaemia is due to insulin resistance and altered glucose homeostasis. If any therapy improves insulin sensitivity and glucose homeostasis will definitely reduces hyperinsulinemia, and will never fail to bring down hyperinsulinemia
https://www.researchgate.net/publication/8654541_Prevalence_of_insulin_resistance_and_associated_cardiovascular_disease_risk_factors_among_normal_weight_overweight_and_obese_individuals?ev=prf_pub
Article Prevalence of Insulin Resistance and Associated Cardiovascul...
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