Insoluble protein used as an immunogen

03 March 2013 1 4K Report

What's the immunogenic characteristics of an insoluble protein, such as a membrane protein? Can we use the precipitated insoluble protein for the immunization of a rabbit, what's the result if someone did it this way?

Yunlong Hu

Large, insoluble, or aggregated macromolecules generally are more immunogenic than small, soluble ones because the larger molecules are more readily phagocytosed and processed

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