COVID-19 binds to ACE2-receptor and initiate a cascade of cytokine-activation inkluding IL1-beta, IL-12, TNF-alpha and especially an increase of IL-6 and might initiate a so-called cytokine storm.
Can prospective studies with patients with and without Corona COVID-19 theoretical show and increase in the incidence of autoimmune diseases in the Corona group , including our patients with dermatological conditions such as Hidrosadenitis Suppurativa, Psoriasis and Atopic Dermatitis ?
Are such studies of relevance ?
Kind Regards:
Carsten Sauer Mikkelsen
Specialist in dermatovenereology
The cytokine storm suppresses synthesis of EPO, and thereby the regulation of the immune system that EPO normally exerts.
I know nothing about dermatology, but it might be the cause of increase in/ worsening of autoimmune diseases. And EPO might be the cure.
https://www.researchgate.net/post/Covid-19_Erythropoietin_EPO_deficiency_syndrome2
(see references 10-13)
Dear Carsten Sauer Mikkelsen, many viruses have been proposed for triggering and initiating autoimmune diseases like: Parvovirus B19, Epstein-Barr-virus (EBV), Cytomegalovirus (CMV), Herpes virus-6, HTLV-1, Hepatitis A and C virus, and Rubella virus. SARS-CoV2 virus might have potentials of being added in the list. long term follow up of the COVID-19 sufferer might give a clue. Thanks for raising this very pertinent issue.
These articles might be of interest:
Article Risk surveillance and mitigation: autoantibodies as triggers...
Article The Receptor That Tames the Innate Immune Response
Newer review "Erythropoietin and its derivatives: from tissue protection to immune regulation" :
https://www.nature.com/articles/s41419-020-2276-8