According to the reaction protocol following for polymer conjugate reaction if the given solvent mentioned is not soluble for the reaction we are going for. So, is it okay to add the desirable solvent in which that first polymer is soluble (following the procedure) and further going ahead with following the protocol or should I just follow the reaction protocol or what should i do any suggestion. THANK YOU!!
(p.s- The solvent used according to protocol is dry DCM and the solvent in which it is soluble is chloroform.)
If the polymer is not soluble in the solvent specified by the reaction protocol (e.g., dry DCM) but is soluble in an alternative solvent (e.g., chloroform), you may consider switching solvents, but this decision should be taken carefully. First, ensure that the new solvent (chloroform) is compatible with the reaction conditions, then check for potential side reactions, stability of reagents, and any solvent-specific requirements (e.g., anhydrous conditions, boiling point, or polarity). If chloroform is chemically suitable and does not interfere with the reaction mechanism, you can proceed with it while maintaining other protocol conditions (e.g., temperature, stoichiometry, and reaction time). However, if the original solvent (DCM) is critical for the reaction’s success (e.g., for solubility of other reagents or intermediates), mixing solvents or optimizing the solvent ratio might be necessary. If possible, seek advice from colleagues or supervisors familiar with the reaction. Ultimately, while deviating from the protocol can be acceptable with proper justification, it requires careful evaluation to avoid compromising the reaction outcome.
You may check the following paper:
Article Prediction of the Solubility of Chloroform in Acrylate Polym...
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Hi ! Syed Madhi Haider Kazmi Thank you it was great help since i was in dilemma about changing the solvent or not.
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