In GWAS, how to decide the covariates (PC or Kinship)?

More Dharminder Bhatia's questions See All

P-nitrophenol acetate assay for esterase and media supernant colour interference. what can be done?

I am performing p nitrophenol acetate assay for esterase enzyme. My media contains a different concentration of peptone (0.5, 2, 5%) and after centrifugation the supernatant is slight yellow....

16 June 2024 4,381 0 View

Can anyone recommend a company that does LC-MS/MS for silver stained gels where I can outsource my samples for proteomics analysis?

Looking for most cost-effective manner to outsource my samples (silver stained gels) for proteomics analysis using LC-MS/MS. If anyone has outsourced samples outside or in INDIA for LC-MS/MS and...

21 April 2024 309 2 View

What could be the cause of getting such blots?

my protein is a nucleolar protein which is tagged with HA, FLAG and myc tag. i have over-expressed it and good GFP expression was observed which is directly proportional to the amount of my...

11 January 2024 2,057 2 View

What is new in Menstrual Health and Hygiene in terms of marketing?

I am researching the taboo behavior around women's menstrual health and hygiene, and exploring ways to shift it towards marketing through better research design.

16 December 2023 2,530 1 View

When I published my article to a journal, it was not Scopus indexed. Now the journal is indexed in Scopus. Will my paper also be indexed now?

The paper was published one year back in a peer-reviewed DOAJ indexed journal by Elsevier. Now the journal has been indexed in Scopus. Will my previously published article in that journal be also...

11 December 2023 4,932 4 View

What are R packages for detecting peaks and peaks area for HPLC chromatogram?

I am performing snake venom fractionation using Reverse-phase HPLC. It generates multiple peaks with different area under the curve. Since I'll be analyzing multiple chromatograms at different...

08 November 2023 9,134 0 View

Can anyone guide how to use the minitab software for optimization studies ?

I want to learn minitab software and how to use that software for optimization studies of the enzyme. How we can find the actual and predicted values from the software.? how we can make Plackett...

23 September 2023 5,983 2 View

Looking for a Topic for my Phd project research which could solve a Problem?

I enrolled for a PhD Programme in Computer Science. For my research work I am looking for a topic to choose which could make an impact and solve a Business problem. my area of interest are Data...

19 March 2023 8,842 4 View

What could be reason for my protein bands not resolving properly?

I have performed venom fractionation using HPLC and run the samples in SDS PAGE. I wanted to know what could be the possible reason for my protein bands to look like this. It should have been...

15 March 2023 3,542 6 View

If I have to perform a spectrophotometric assay using p-nitrophenyl acetate, then the standard graph should be made of p-nitrophenyl??

the standard graph of p-nitrophenyl acetate, how we can make it, which concentrations can be used?

04 August 2022 841 0 View

Is it necessary to covary exogenous constructs in a structural model?

I am working on a SEM model where i have 7 latent variables (6 exogenous and 1 endogenous). In AMOS when I co-vary the exogenous constructs, only 2 paths are coming significant out of 6. But when...

03 August 2024 6,028 4 View

How to estimate sample size for GWAS of continuous and discrete traits? What are the pre-requisites?

Genome-wide association study (GWAS) Continuous traits: eg. Height Discrete traits: eg. Eye color

28 July 2024 286 0 View

What analysis to use for an dependent variable with repeated measures and a independent variable only measured once?

Hi all, I am trying to use mixed effect model to analyze my data, which including a baseline measurement for my exposure (A), and repeated measurements for the outcome (B). I do have some...

17 July 2024 8,682 3 View

How do the institutions of Family, Marriage and Kinship contribute towards the Socialization of young minds?

Institutions of Family, Marriage and Kinship contribute towards the Socialization

20 June 2024 7,056 4 View

Addressing Multi-Level Factors in Group-Based Trajectory Modelling: Comparison of Methods and the Role of the Flexmix Package?

I'm currently working on a project involving group-based trajectory modelling and am seeking advice on handling multi-level factors within this context. Specifically, I'm interested in...

16 June 2024 8,765 0 View

Generalised Linear Mixed Models Assumptions and Covariate Identification?

Hi everyone. When running a GLMM, I need to turn the data from wide format to the long format (stacked). When checking for assumptions like normality, do I check them for the stacked variable...

12 June 2024 4,517 1 View

Path analysis: Do I control for covariate effects on all endogenous variables (and mediator) or just DV?

I did research and the studies suggest controlling for the effects of covariates on all endogenous variables, including mediator variables, to improve model accuracy and reliability. I want to...

04 June 2024 1,914 3 View

A variable moderating multiple relation - how can I test hypotheses using amos?

How can I analyse the relationship between five independent variables and one dependent variable, with a moderating variable influencing each of these five relationships? How can I test hypotheses...

03 June 2024 6,221 1 View

Can we calculate the covariance between a random variable y and a nonrandom variable x?

Variable x is a controllable, and variable y is a random varialbe. Also, y=b*x+u, and u is a random iterm. So x and y is correlated. But, if we calculate the covariance between x and y, according...

02 June 2024 1,829 3 View

Logistic regression with time varying covariate?

I have two outcome variables: 1- binary 2- repeated measure There is only one independent variable which is time varying covariate Iam looking for the article to write the Stat for: 1-...

01 June 2024 9,890 3 View

Hugo L Gallardo-Blanco

This link (free) may be useful to the analysis of population stratification, in general, the ten highest PCA may be included as covariates.

http://doc.goldenhelix.com/SVS/latest/svsmanual/principal_component_analysis.html

And this other link to GWAS eBook (free):

http://goldenhelix.com/resources/ebooks/GWAS.html