In thinking about stem cell interactions with tissues as a possible cause of cancer, the basic idea of DNA damage is relevant on the opposite side of the metabolism. DNA is involved in producing the molecules that interact in the tissue system, and regulating the cells in the tissue, but it is interesting to wonder which side of the metabolism causes cancer. Is it the DNA or the cell interactions?
Thank you Arpan De. I am interested in how stem cells interact with tissues and how those tissues normally metabolize -something like a circadian rhythm response - and how this may be out of a normal range of balance in cancers or cancer origins.
I am wondering if the cancer cells originate with DNA in the cell, say by solar radiation in space, or if cancer may be caused by tissue maintenance by stem cells, or if it is the same in all cases.
Metabolic changes in cancer cells and stromal cells are secondary to malignant transformation. There is no evidence that Metabolismall y itself can produce cancer.
Very old research showed that hypoxia on the other side could lead to cancer probably through genetic instability.
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