How covid19 may influence the heath state of sickle cell patients?
We should consider sickle cell as risk factor for complications?
Viral infections can precipitate sickle cell crisis.
Saudi Arabia has a high incidence of sickle cell disease. However the incidence of Covid-19 is currently low. So I have not yet had to treat a patient with Sickle Cell disease and Covid-19. I will update you know once I do.
The difficulty with managing Sickle cell disease in a patient with Covid-19 is that NSAIDs are contraindicated because they increase risk of mortality. All other analgesics (besides paracetamol) are sedating and so may increase the risk of complications. Aggresive hydration may also precipitate the onset of lung injury.
I will therefore initially use gentle hydration paracetamol and 5% lidocaine patches to manage sickle cell crisis during the Covid-19 pandemic.
Another challenge is that blood supplies for transfusion have been depleted. This is because of a fall in donors. So it will be difficult to administer blood to these patients when indicated.
I would be grateful if you could consider this question.
How can we maintain supplies of blood for transfusion during the Covid-19 pandemic?
https://www.researchgate.net/post/How_can_we_maintain_supplies_of_blood_for_transfusion_during_the_Covid-19_pandemic
You can find a regularly updated list of specific information/recommendation brochures for patients and professionnals concerning Covid-19 infection and rare blood diseases including SCD on the site of EuroBloodNet:
https://eurobloodnet.eu/covid-19
Also if you follow SCD patients then you can update the Global Registry developed by the Medical College of Wisconsin, your data will help us all worldwide to decipher the details of the Covid-19 infection in patients with SCD:
https://covidsicklecell.org
Is there any likelihood of coronavirus involvement in a trait of sickle cell anemia?
for sickle cell trait, i'll consider like average risk of main population
Should health professionals with sickle cell trait do social isolation at home?
Dear Alano, as Alexandra already stated, there is no indication at the present time that TC are more at risk than the rest of the population. So there is no restrictive measure to be taken.
At contrary, I suspect some advantages in TC... We plan to make an IEF in the covid cohorts in Kinshasa. Wait and see...
COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the
Porphyrin to Inhibit Human Heme Metabolism.
doi.org/10.26434/chemrxiv.11938173.v6
Implication of coronavirus infection in sickle cell disease? And sickle cell trait?
I think that for the moment, it is difficult to draw conclusions on coronavirus on sicklanemia S. Let us wait to see the results of the various studies which will be carried out in DRC and throughout the world. Surely, there will be advantages and disadvantages of the coronavirus on sicklanemia. We keep learning from this virus.
Il est sans équivoque que le drepanocytaire soit vulnérable face à COVID-19.
Il faut aussi des mesures spécifiques de prévention de COVID-19 chez les drepanocytaires.
Un dépistage ciblé de la drépanocytose auprès des patients COVID-19 réduirait la létalité de la pandémie.