Hi all,
Goin thru the online papers that describe immunisation and challenge experiments normally draws to a conclusion that the immunisation gives protection or even partial protection to the host. Are there any papers that showed no protection after the immunisation, even though the immunisation experiments are able to induce immune responses in the host? Thank you.
Dear Ho Sue Kim,
Vaccination against the bacterial pathogen Renibacterium salmoninarum, which causes bacterial kidney disease (BKD) in salmonid fishes, may elicit a humoral immune response without protection against BKD. I have attached a review book chapter on BKD vaccination, which cites unsuccessful as well as successful vaccine trials for this pathogen.
Best regards,
Diane Elliott
In reality there are only articles that tend to show that seroconversion goes hand in hand with protection.
But the great majority of the works carried out all over the world lead to the opposite: an immune response giving no protection.
But these works are never published, without interest! What's the point!
For example: Influenza, HIV, Dengue, CMV, Leptospira, Pseudomonas, cancer cells ....
Rolf Zinkernagel has extensively address this subject. I recommend to you some reviews that includes key references with the experimental data:
Immunological memory ≠ protective immunity.
Zinkernagel RM.Cell Mol Life Sci. 2012 May;69(10):1635-40. doi: 10.1007/s00018-012-0972-y.
Immunological memory: lessons from the past and a look to the future.
Farber DL, Netea MG, Radbruch A, Rajewsky K, Zinkernagel RM.
Nat Rev Immunol. 2016 Feb;16(2):124-8. doi: 10.1038/nri.2016.13.
Antiviral antibody responses: the two extremes of a wide spectrum.
Hangartner L, Zinkernagel RM, Hengartner H.
Nat Rev Immunol. 2006 Mar;6(3):231-43. Review.
Other examples of induction of non-protective immune responses you can find in:
Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults. MacLennan CA, et al. Science. 2010 Apr 23;328(5977):508-12. doi: 10.1126/science.1180346.
In the vaccine development field is plenty of examples of experimental vaccines that despite being highly immunogenic does not confer protection. i.e. the anti-Salmonella flagella, LPS and ribosomal experimental vaccines.
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