Immune tolerance induction treatment with different plasma derived factor concentrates?

04 January 2016 1 9K Report

Considering the amount of von Willebrand factor in PDF VIII , what type of PDF composition (amount of vWF) is better for ITI in Hemophilia A?

Omer Iqbal

Hi Peter,

This is very interesting question. There is a debate whether the low dose regimens (50 IU FVIII/kg, three times a week is better or 200 IU FVIII/kg, once a day regimen is better and advantageous Please refer to the following reference for more details. I am not totally aware of the REScue study which would have shed some light on this subject.

The immune tolerance induction (ITI) dose debate: does the International ITI Study provide a clearer picture?

Ettingshausen CE1, Kreuz W.

Omer

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