If there is osteoporosis in the setting of adynamic bone disease in ESRD on hemodialysis, what is the experiece with Prolia in such setting?

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Oscar Rosero

Hello, in adynamic bon disease, we can´t use denosumab, because risk of Hypocalcemia. the problem is the definition of adynamic bone disease.

Dimitar Vasileff Georgieff

Denosumab is not perfect treatment. Also, the hemodialysis is a contraindication because diminish the clinical effect of Prolia.

https://www.researchgate.net/post/Do_you_think_that_the_biological_therapy_has_amoral_concept_to_be_continued_to_the_end_of_life