Yes, you should be able to inject without problems

Thank u..i am about to clear the doubt about the vehicle irritation and absorption of drug and effect on peritoneal membrane?.

It will depend on the compound that you r going to inject, the purpose of giving the injection(like pharmacokinetic or drug effect or dose effect study or toxicology study) and the volume you are going to inject. If the compound is lipophilic, and you inject it intra peritonially, the absorption of the drug will be very slow, since the drug may preferentially remain in peanut oil, and the peritoneum do not have any lipase enzyme to degrade it (as happens in stomach and intestine). So it may not be good if you are doing a pharmacokinetic work . If you are working to find out the pharmacological effect, depending upon the lipophilicity/ lipophobicity of the compound, the time for effect may vary and you may have to extend the period of observation. The final volume is also important, since DMSO can irritate the mucus membrane if its content is high. An irritated mucus membrane may hasten the absorption (and may lead to toxicity) or may inhibit the absorption altogether. And always remember that peanut oil can( though rare) produce idiosyncratic allergic or anaphylactic reactions, even by oral route

I think it will affect the bone marrow cell. We found that DMSO had multiple effects, especially on differentiation. it even affect the insulin sensitivity. you should make it as low as possible

Try it and let me know your results. Look my dear friend.... You need to know what is the final volume of the DMSO. What is the compound your are referring to. What will happen if you wish to give it as a colloid (no i am not referring to the point that it will enter at a slower rate in the system). All these factors will dictate the conditions required for your answer.

Hello,

could you please tell me the result?

I have the same problem right now!

@Rasha, I did it. I didn't find any difficulty while injecting and no symptoms after injecting in to mice.

Thank you Madhu

Madhu C Lingaraju did you use an specific peanut oil for injection? was it sterile? I am having trouble finding it here in Brazil. Thank you

I wouldn't dare do do that i.e inject DMSO (in whatever form) to give an intra peritoneal injection in a small animal like mouse. My strategy would be to make a emulsion with a suitable wetting agent and then inject it intraperitonealy. This too may be risky.

Hello,

how much volume (per mice Kg) you do injection? I am working on a similar way to do IP injection, did you do injection per day? How many consecutive days you use? Thank you