It can be helpful!

Article Defective Circulating Regulatory B Cells in Patients with Di...

Cardiomyopathies are quite heterogeneous. Regarding congenital cardiomyopathies you may be interested in Barth syndromeArticle Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidat...

Dear Kunal Sikder

I agree with Andri Leó Lemarquis that cardiomyopthies are heterogeneous and if associated with primary immunodeficiencies, the mutations are acting in T cells (Omenn syndrome or calcium channel (ORAI-1) deficiency) or neutrophils and macrophages as in the case of Barth syndrome, rather than B cell immunodeficiencies.

There is however a rare primary immunodeficiency syndrome with B cell signalling defects called TWEAK deficiency with mutations in the TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) gene that have both B cell/ antibody defects & seem to associate with cardiomyopathy.

Please see the attached papers for further information.

http://www.pnas.org/content/110/13/5127

Article A Novel Role for Tumor Necrosis Factor-Like Weak Inducer of ...

I hope that helps!

All the best,

Michael

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Thank you everyone

Dear Kunal Sikder

you may also consider Rubinstein Taybi Syndrome. We have recently published a case with combined immunodeficiency and cardiac defects.

Pediatr Allergy Immunol. 2018 Aug 4. doi: 10.1111/pai.12968. [Epub ahead of print]

A novel EP300 mutation associated with Rubinstein-Taybi syndrome type 2 presenting as combined immunodeficiency.

Saettini F1, Moratto D2,3, Grioni A1,4,5, Maitz S6, Iascone M7, Rizzari C1, Pavan F1, Spinelli M1, Bettini LR1, Biondi A1,5, Badolato R2,3,8.

regards

Francesco