I am working on a meta-analysis where i have extracted the data directly from KM curves via web plot digitizer to calculate HRs for the studies that reported only KM Curves. One of the study has three curves and web plot digitizer would give me a total of three groups. I was wondering if it is appropriate to combine the data for two of those groups and calculate an overall HR for a meta-analysis? Keeping in view that it is a time-event data and there's censoring too. I tried using the method elaborated by Cochrane but it gave me a really wide confidence Interval.
Anyone having any lead of how to deal with this?
Hello Maurish Fatima
I do not agree with this idea.
"if it is appropriate to combine the data for two of those groups and calculate an overall HR for a meta-analysis?"
Perhaps it is better to abandon this study.
Hello Maurish Fatima,
In my experience, estimated data (e.g.: data retrieved from KM) will usually give you a "really wide" confidence interval as you say. Personally, I would have computed all three groups as three individual studies for the meta-analysis (in addition to other studies).
Cheers!
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