Does anyone have an idea for bioinformatics research on stem cells and differentiation subject, based on gene expression profiling data or OMICS data?
I and some other researchers need a good and new idea for a research to start. Please add your ideas to make a big idea bank on this subject.
Differentiation implies the coordinated motion of 'genome as a whole' and cannot be restricted to the identification of single 'mastr genes' this is why I am convinced the OMICS can give a very relevant contribution to the problem if and only if we acquire a statistical mechanics global approach to the quantification of correlation and order during the differentiaion process, here are some worked examples:
http://www.mdpi.com/1099-4300/19/11/584
http://www.mdpi.com/1099-4300/20/1/13
Article Cell Fate Decision as High-Dimensional Critical State Transition
http://stemchecker.sysbiolab.eu/
Article StemMapper: A curated gene expression database for stem cell...
Have a look at these databases you will have a overview.
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