Nature Genetics 41, 1088 - 1093 (2009) doi:10.1038/ng.440
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 × 10−157) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 × 10−9) and 5′ to the PICALM gene (rs3851179, P = 1.9 × 10−8). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 × 10−10, odds ratio = 0.86; rs3851179, P = 1.3 × 10−9, odds ratio = 0.86).
thank you Ram Nath Mishra for reply
but i whant database for Alzheimer's disease (AD)
Okay but your original question mentioned DATASET and not database.
Hi, could you be more precise? What would you like to do with this dataset? Test hypotheses? Do some blood assays? etc.
thank you Christophe Tzourio for reply
i whant data for EEG signal.
Cases Namely,
- Data of Healthy people.
- Mild Cognitive Impairment (MCI).
- Alzheimer's disease (AD).
to Classification by Adaptive Neuro-Fuzzy Inference System (ANFIS).
Check in the net under ADNI and NACC. These are large AD datasets also including normal controls. I assume EEG data will be available at least for some of the participants.
Thank you Quan Ma
I want EEG signal or EEG frequency for Alzheimer's disease
Thank you Ekaterina Galkina
The NACC dont have EEG signal or EEG frequency
only have age and sex ...........
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