I understood that full PPAR agonists (like Thiazolidinediones) resulted in severe side effects and this is why the switch to exploring partial agonists was made.
But doesn't the partial activation of the receptor produces a reduced effect on the PPAR gamma? How would this help in remediating Type 2 diabetes then?
Hi Dr Ashley D'Souza . See the following useful RG link: Article Structural basis for PPAR partial or full activation reveale...
Kindly see also the following useful link: https://www.sciencedirect.com/topics/medicine-and-dentistry/peroxisome-proliferator-activated-receptor-gamma-agonist
Also kindly see the following useful RG link: Article Pioglitazone and PPAR-γmodulating treatment in hypertensive ...
Moreover the following RG link is useful : Article Medium Chain Fatty Acids Are Selective Peroxisome Proliferat...
Aref Wazwaz Thank you very much Sir for your time in answering this question. I have got my answer through the links provided by you
You are most welcome dear
Dr Ashley D'Souza .
Wish you the best always.