I want to work SNPs of RA in case-control study. I checked LD of SNPs. Should i exclude the proxy SNPs which are in LD with selected SNPs?

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Naveed Hussain

@ University of Tuebingen @ Md. Mostafijur Rahman Thanks for your answers. May u guide me why we exclude proxy SNPs?? If any SNP of our interest show positive association, then proxy SNPs which are in LD may also positive association ???

@ Christian G Meyer. To deduce reasonably an association do we exclude proxy SNPs ? May u kindly provide me literature reference to mention it?

why do we exclude proxy SNPs?? If any SNP of our interest show positive association, then proxy SNPs which are in LD may also positive association ???