I have synthesized a polymer of PAMAM and I see some traces of ethylenediamine (used for the modification) in the NMR. I want to know is there any method I can purify my polymer to get rid of the ethylenediamine? As purification of this polymer is difficult. Both the ethylenediamine and polymer are soluble in the same solvent.
Two things -
If it isn‘t a large amount, and is soluble in water, you can use an aqueous SEC or GPC method like Sephadex to separate - the PAMAM is much larger than the ethylene diamine.
if the PAMAM is carboxy terminated instead of amine terminated, you may be able to use acid - base chemistry for separation. If it is amine terminated, this won’t work.
Dear Anuja Kulkarni, please have a look at the following document, hope it will be usefull. My Regards
https://doi.org/10.1021/ma300485p
Check https://www.sciencedirect.com/science/article/pii/S1878535220301490
https://www.sciencedirect.com/science/article/pii/S2468519417302033
Also check here Anuja
https://pdfs.semanticscholar.org/5432/112f70e369961da3741b479fa90281dfb56f.pdf
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