What should be the zeta potential values of a drug in drug delivery?
Dear Kiruthika,
Attached is a recent review on the requested topic.
Hoping this review will be helpful,
Rafik
20-90 degrees celcius; Refractive index range: 1.2 to 1.65; in MALVERN Nano ZS90 with device.
There is not a set of "good" zeta potential values for drug delivery particles. If the particles are entirely electrostatically stabilized then more than ~30mV is probably a good guideline (i.e. more positive than +30mV or more negative than -30mV). However, often there will be a steric stabilization component as well, which means lower zeta potential values can still lead to a stable formulation. In the extreme case, for entirely sterically stabilized particles, even 0mV could lead to a stable formulation.
The attached article
"Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems" may be helpful.
Warm regards
Dear Kiruthika
Preferrred ZP for stable formulation is -30 to +30. charge depends on the formulation excipients used. more the charge more the formulation stability and shelf life. potential values can be varied and should be planned based on the on site of action and route of delivery. so there is no standard rule or standard ZP for drugs using in drug delivery, it can be changed, depending on your project.
Regards
Hi, Can I know which procedure or addition of which excipients would be helpful to prepare a nanosuspension with almost 0 mv Zeta potential? Is it really possible?
Hi, Can I know which procedure or addition of which excipients would be helpful to prepare a nanosuspension with almost 0 mv Zeta potential? Is it really possible?
Hi, Can I know which procedure or addition of which excipients would be helpful to prepare a nanosuspension with almost 0 mv Zeta potential? Is it really possible?
There is no angel and demon numbers in zeta potential measurement for drug delivery applications. Conventionally above +30 mV or below -30 mV is represent their colloidal stability of the particles. Further, It indirectly tells us the surface charge of the nanoparticles (caution: it doesn't measure surface charge). You may not able to get above or below 30 mV values for PBS solution and it always show 0 mV. Because, the Zeta potential measurement strongly depends on pH, temperature, counterion concentration, counterion size and counterion valency.
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