Although it would be more convenient for us if we'd get the mice from India, but thank you so much for this information, David S Gardner. That was helpful.

I don't think it's worth producing the mice from scratch since they already exist. It would probably be more expensive, and you would have to fully characterize your new mice line (plus, producing a KO take a long time!).

Alternatively, you could ask one of the the producers of the TLR2-KO, e.g. Carsten J. Kirschning, or somebody that used it and thus that have it in their colony, e.g for TLR4-KO: Riddell et al., 2011. You can probably search in the literature for more people that have used those mice.

Thanks, Jean-Nicolas Audet.

NII, Delhi has TLR4-/- (C3H/HeJ) mice 

Thanks Nidhi. I know that NII, Delhi has got TLR4 -/- mice, but I have no idea about TLR2 -/- mice. Do you know where shall I find TLR2 -/- mice? And could you please give me any contact details to get TLR4 -/- from NII? To whom I shall contact that I don't know.

TLR2-/- were there in ICGEB earlier. Not sure about present status.

Okay. Thank you so much, Nidhi.

TLR 2 ko mice are present in ICGEB, you can contact them.

Thank you so much, Parmeshwar Katare.

good like for that