There are very few methods in literature for drying nanoparticles - mostly freeze drying is used, few others are spray drying, oven drying, evaporation etc. However, these often lead to agglomeration/change in size and also in some cases properties. I am interested in a simple and effective method of drying.
Supercritical CO2 works pretty fast, you transfer samples to methanol, and then flow the supercritical CO2, takes about 30 min, and all solvent is gone. This works only for drugs that are strongly adsorbed to the particles though (e.g. electrostatically), otherwise the CO2 could take away the drug. You can always do a test before applying. We have a Samdri PVT that works great for us (http://www.tousimis.com/critical_point_dryers/detail.html?Pid=8755B)
Spray drying might be another option. This link is just to get your started looking into it http://en.wikipedia.org/wiki/Nano_spray_dryer
why dont you try "spray freeze drying"?
It dose not effect on size or other properties.
It is excellent
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology
- Nanostructured Materials
- Nanoparticles