Hi !
I'd like to know if hypoxic cells communicate with the surroundings cells (that are also hypoxic or not hypoxic). I mean I assume they release signals that could lead to angiogenesis or other mechanisms but I'd like to know if there is a cooperative effect with the other cells of the region to sayto them : "let's all reduce our metabolism so that we all burn off less oxygen and nutrients, so that we will live longer".
And would you know if that behavior changes for tumor cells ?
And if you know articles about that topic, could you please give me the reference ?
Or even if they don't emit signals, do cells release molecules that can have an effect on the sourrounding cells metabolism ?
Thank you
Joseph
That might help a bit already:
Article Feedback regulators of hypoxia-inducible factors and their r...
Article The cancer stem cell niche(s): The crosstalk between glioma ...
Article Glioblastoma: Defining Tumor Niches
Article Hypoxia-Modified Cancer Cell Metabolism
http://www.jbc.org/content/292/41/16825
https://www.nature.com/articles/oncsis201550
I never followed up on this study but maybe this will help: Article Redistribution of glutathione in the ischemic rat retina
It has been reported that some miRNAs are upregulated in response to hypoxia, as described for retinoblastoma (Xu et al. Int J Oncol 2011;38:1385–93), for bladder cancer (Blick et al. Br J Cancer 2015;113:634–44) and for gastric cancer (Ayremlou et al. Cancer Biomark 2015;15:851–60).
Sascha Seidel Michael Schuette María Luisa Caballero Thank you for your help
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