Greetings all.
Anybody knows of some hard evidence showing that Dypiridamole and / or Clopidogrel use can alter exams used on the diagnosis of hypergoagulable states (MTHFR, Lupus Anticuagulant, Protein C / S deficiencies, Protein C resistance etc) and what should be the countermeasures (eg, 7 days without taking the medicines prior to collection of exams)?
The issue is even more complex, including antiphospholipid syndrome/circulating anticoagulant. One either has to reduce platelet "stickiness" by prolonging platelet responses to epinephrine/collagen or use coumadin. The heparin "safer substitutes"
do not work...
I would suggest a TEG, thromboelastigraph, to help determine the source of the hypercoagubility. TEG will differentiate between factors, fibrin and platelets. A platelet mapping will also show you the effects of medications on the ability to clot. This may show you any underlying coagulation issues without taking a patient off an anti-coagulant.
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