Hi all,
How could chronic continuous glucose monitoring (instead of strips) help preclinical research moving forward?
http://www.datasci.com/glucose/home
Thanks.
As there are many ailments associated with Glucose level in Blood. So it becomes very important and Vital for Pre-clinical studies. Somewhere you will find Glucose tolerance / Intolerance, so it will help in designing further experiments or possible regime.
Continuous monitoring, provided it is accurate and reliable, can provide detailed profiles of glucose over the test period of time. For example in the case of oral or intraperitoneal/iv glucose tolerance, for practical reasons one is limited by how many time points can be used in the glucose or insulin profile. Therefore one often picks the time points that may be most relevant: 0, 15, 30, 45, 60, 90, 120 min is a decent spread. But even so, the exact glucose peak may be missed. Continuous monitoring could easily eliminate missed peaks.
More to the point, if a reliable continuous monitoring system can be designed that lasts for a long time (ideally a year or longer), it stands to make glucose control in type 1 diabetics much easier by allowing the monitor to control the insulin pump.
Thus far, such monitoring systems have not proven fully reliable in the long-run, hence the need of preclinical testing.
Hyperinsulinemic-Euglycaemic Clamp may be a good choice of continous glucose monitor
SCGM in clinical studies adds much more information during metabolic investigations especially if you are interested in the course of any response e.g. nutritional or physical activity. I would expect another option for the interpretation in the discovery of biomarkers.
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