From my literature survey i have found nitro is more electron deficient than nitrile. But my Ru hydride catalyst is selective towards nitrile than nitro in reduction. i want to know the role of catalyst in chemoselectivity.
It makes sense. The reduction catalyzed by ruthenium hydrides goes through a hydrometallation step, very well described in the literature. This process does not takes place over nitro groups. For this kind of reduction, you should use Fe/HCl but you should see about the compatibility over the nitrile group.
Best regards!
yes its in same substrate. even if i have ketone, aldehyde and nitro in same substrate it selectively reduce nitro.... @viktor mojr
Thank you@ Felipe Verdugo. But still i want to know the role of homogeneous catalyst in chemoselectivity.
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