Forget the legality of it all...Never a good idea to inject animal protein of any sort into humans. You will induce an anti-rabbit antibody response in the person. And if the person gets another dose (or somehow gets exposed to rabbit antibodies) after a memory response is induced... it'll cause a type III hypersensitivity.

There are very limited cases where this is okay... the most obvious one is anti-venom (which is horse serum/polyclonal antibodies against venom, usually snake).

You can perform a degradation of the Fc region of your antibody using papain and pepsin. However, your antibody could not generate opsonophagocytosis by macrophages.

I hope it helps you.

Greetings.

There are several products developed from polyclonal rabbit antibodies that are commonly used in humans.

The best known product is probably Genzyme ATG which is used against transplant rejection and works perfectly well and is very well tolerated.

There is no prohibition to use polyclonal antibodies of animal origin (rabbit or horse), but be careful though, because if these reagents work it is primarily because they target the immune system in repressing it completely and avoiding the anti-drug response as much as possible.

Would agree with above. Overall immune suppression and activation seem to be the mechanism for many vaccinations (Flu). Doesn;t remove the virus, just revs the Immune system and I suspect makes us more vulnerable to more nasty pathogens.

We jumped on the artificial foods better than nature bandwagon (margarine, polyunsaturates).

We jumped on the Genetic Code is everything bandwagon (23 and me).

We jumped on the immune vaccine bandwagon - which to my eye is causing devastating auto-immune problems.

Too much proprietary money in this business.

Thanks a lot for all great and helpful answers.

An additional thought.

Small things are not seen well by the immune system (parts of virus, bacteria). Adjuvant is often added, but research is hard pressed to find effectiveness related to antibody titer.

https://en.wikipedia.org/wiki/Antigen_processing

It appears to be the response of the immune system that is important more than the stimulation of the immune system. Look at Polyclonal vs Monclonal, and for instance, effect of antibiotic on chlamydia:Article Azithromycin-induced block of elementary body formation in C...

We need to realize that controlling one part of a complex process may not be the best in the long term. Our Medicine does this all the time. An example is Curcumin spice effects on disease. Because it affects dozens of processes it has long been ignored as a therapeutic. The Experts are producing flawed guidance.

The problem I face as a clinician is that there are few clinicians available to go to who have knowledge about these things. The expertise in town is competing economically as example so hard to find them.

Dear Dr Rozita Nasiri,

You could use the rabbit polyclonal antibodies as an antidote for the human with following precotions:

1. Rabbit polyclonal antibodies must be produced by a certified institution with detailed characteristics of their antidote activity.

2. At first you have to make an intradermal injection of 0.1 ml and look at the response within 20-30 min. Appearance of intensive redness or papula >5 mm in diameter, itching prove to possible intolerance of these polyclonal antibodies and you have to give up with your attempt to apply them.

3. If intradermal response is negative, final injections you do in 2 steps: at first 1 ml, so called hyposensitizing dose by Bezredka, following the common state of patient within 20-30 min.

If no pathological reactions appear, you have the right to inject the rest of polyclonal antibodies pool.

Take into account that repeated application of allogenic (rabbit, horse) is more dangerous than the first one.

Thanks a lot for all great comments