Basically this is organic compound of free base and contains Amide and Amine groups.If we tried Acid base treatment it is not extracting into any organic solvent.
Ammonium chloride has a fairly high vapor pressure. You should be able to remove it in a vacuum oven. Without more information it will be difficult to give better answers.
you might have tried this already but the first think I would try is distillation of the compound of interest. The ammonium salts have a boiling point over 500 ˚C so it will not distill.
Basically we are synthesizing 2-Amino Butanamide via amidation by using Aq Ammonia .In this reaction 1 mole of NH4Cl is forming.
Due to high solubility nature of our compound in water we are unable to extract compound from water. Finally we distilled water completely and tried to soluble in Ethyl acetate ,MDC & CHCl3 to filter NH4Cl.But it is not getting soluble.Please suggest to remove this NH4Cl.
Have you tried to distill off your compound? butanamide have a boiling point of 216 according to alfa so it should be easy to separate it by distillation under pressure.
You may try to use isopropanol as the extracting solvent. I used to remove NH4Cl from amidines hydrochlorides by solving them at RT or slight heating and separating from undissolved inorganic salt. Acetonitrile is pertinent too, if able to dissolve your target substance.
After your reaction is complete neutralize your reaction mixture with dilute solution of NaOH with stirring ammonia gas will release and NaCl. then you can extract your reaction product using chloroform or any other organic solvent.