characteristic of Ag and Ag+.
I need to know how Ag NPs would be toxin?
Do you think with fabricate of metal Alloys, we can control this toxicity?
Toxicity of Nanoparticles
Engineered nanoparticles (NPs) are commercially produced materials having at least one dimension less than 100 nm. Nano-technology has brought a great revolution in the industrial sector. Due to their distinctive physicochemical and electrical properties, nano-sized materials have gained considerable attraction in the field of electronics, biotechnology, and aerospace engineering. In the field of medicine NPs are being employed as a novel delivery system for drugs, proteins, DNA, and monoclonal antibodies. So far, NPs have been prepared from metal and non-metal, polymeric materials and bioceramics. The majority of NPs having medical applications are liposomes, polyethylene glycol, and dendrimers . Humans are exposed to various nano-scale materials since childhood, and the new emerging field of nanotechnology has become another threat to human life. Because of their small size, NPs find their way easily to enter the human body and cross the various biological barriers and may reach the most sensitive organs. Scientists have proposed that NPs of size less than 10 nm act similar to a gas and can enter human tissues easily and may disrupt the cell normal biochemical environment.
Nanomaterials of different substances and their toxicity
NPs of metallic substances
Aluminum oxide
Aluminum-based NPs contribute 20% to all nano-sized chemicals. aluminum-based NPs are being used in many areas such as fuel cells, polymers, paints, coatings, textiles, biomaterials etc .
The aluminum oxide NPs, at concentrations of 10, 50,100, 200, and 400 µg/mL possess no significant toxic effect on viability of mammalian cells. Balasubramanyam et al have reported that aluminum oxide NPs (30-40 nm) possess dose-dependent genotoxic properties. They assessed genotoxicity with comet assay and micronucleus test using rat blood cells. The result of another study using mouse lymphoma cells line also suggest that aluminum oxide NPs (
Toxicity of Nanoparticles
Engineered nanoparticles (NPs) are commercially produced materials having at least one dimension less than 100 nm. Nano-technology has brought a great revolution in the industrial sector. Due to their distinctive physicochemical and electrical properties, nano-sized materials have gained considerable attraction in the field of electronics, biotechnology, and aerospace engineering. In the field of medicine NPs are being employed as a novel delivery system for drugs, proteins, DNA, and monoclonal antibodies. So far, NPs have been prepared from metal and non-metal, polymeric materials and bioceramics. The majority of NPs having medical applications are liposomes, polyethylene glycol, and dendrimers . Humans are exposed to various nano-scale materials since childhood, and the new emerging field of nanotechnology has become another threat to human life. Because of their small size, NPs find their way easily to enter the human body and cross the various biological barriers and may reach the most sensitive organs. Scientists have proposed that NPs of size less than 10 nm act similar to a gas and can enter human tissues easily and may disrupt the cell normal biochemical environment.
Nanomaterials of different substances and their toxicity
NPs of metallic substances
Aluminum oxide
Aluminum-based NPs contribute 20% to all nano-sized chemicals. aluminum-based NPs are being used in many areas such as fuel cells, polymers, paints, coatings, textiles, biomaterials etc .
The aluminum oxide NPs, at concentrations of 10, 50,100, 200, and 400 µg/mL possess no significant toxic effect on viability of mammalian cells. Balasubramanyam et al have reported that aluminum oxide NPs (30-40 nm) possess dose-dependent genotoxic properties. They assessed genotoxicity with comet assay and micronucleus test using rat blood cells. The result of another study using mouse lymphoma cells line also suggest that aluminum oxide NPs (
There are many publications on the subject matter. The following four are some examples:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818642/
[2] https://www.ncbi.nlm.nih.gov/pubmed/22024958
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826769/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993170/
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Materials Science
- Thin Films and Nanotechnology